Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia

A Nguyen; P Cannon; M Kandel; TV Nguyen; L Baird; G Wong; NJ Hannan; S Tong; L Bartho; TJ Kaitu'u-Lino

Journal article

Cell surface associated protein mucin 15 (MUC15) is elevated in preeclampsia

A Nguyen, P Cannon, M Kandel, TV Nguyen, L Baird, G Wong, NJ Hannan, S Tong, L Bartho, TJ Kaitu'u-Lino

Placenta | W B SAUNDERS CO LTD | Published : 2023

DOI: 10.1016/j.placenta.2023.07.013

Abstract

Background: Mucins are a family of proteins that protect the epithelium. A particular type of mucin, MUC15 is highly expressed in the placenta. This study aimed to characterise MUC15 in preeclampsia and investigate its role in placental stem cell biology. Methods: MUC15 mRNA and protein were measured in placentas from patients with early onset (<34 weeks’ gestation) preeclampsia. Circulating serum MUC15 was measured via ELISA. MUC15 was localised in the placenta using in situ hybridisation. MUC15 mRNA expression was measured across differentiation of human trophoblast stem cells (hTSCs) to syncytiotrophoblast and extravillous trophoblasts. MUC15 was measured after syncytialised hTSCs were cu..

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University of Melbourne Researchers

Ping Cannon Author

Vi Nguyen Author

Natalie Hannan Author

Stephen Tong Author

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Grants

Awarded by Japan Agency for Medical Research and Development

Funding Acknowledgements

Funding for this work was provided by National Health and Medical Research Council Fellowships to TKL (#1159261) , and ST (#1136418) and Australian Research Council Fellowship to NH (FT210100193) . funders played no role in study design or analysis.